PREVORA is high-concentration and long-lasting antiseptic coating that is professionally applied to the patient’s teeth. By inhibiting the bacteria that cause tooth decay, PREVORA offers an effective and convenient solution for addressing oral dysbiosis.


The accompanying Summary of Product Characteristics (SmPC) should be consulted before use:

Prevora 100mg/ml Dental Solution SmPC

PREVORA is easily administered by dental hygienists, dental therapists, or dental nurses*, making it suitable for various healthcare settings.

PREVORA has been used in North America for 20 years. Over the past two decades it has garnered a solid evidence base from both clinical studies and real-world experience,1-6 receiving regulatory approvals from the MHRA (UK – PL30669), HPRA (Ireland – PA1205) and Health Canada (DIN 02046245) for the prevention of root and coronal caries in high-risk adults.

PREVORA therefore provides oral healthcare professionals with a valuable new product for treating oral dysbiosis in their patients.

*Dental nurses must be working under the direction of another registrant, who will also carry out the original screening and treatment decision, when applying PREVORA.

PREVORA with its unique formulation and clinical profile, offers several key features for managing oral dysbiosis:

Mechanism of Action:

PREVORA utilises a clear, protective chlorhexidine coating as its primary active ingredient. Chlorhexidine is a well-established antiseptic agent known for its antibacterial properties, making it highly effective in reducing the bacteria that cause tooth decay.7,8

Extended Protection:

PREVORA contains a high concentration of chlorhexidine (10%) and offers long-lasting protection. Chlorhexidine has a well-established ability to strongly bind to the dentition, resulting in a sustained-release mechanism and a longer duration of antibacterial action.9 Furthermore, a higher concentration of chlorhexidine is associated with a longer treatment effect.10

High Efficacy in High-Risk Adults:

PREVORA has been shown to be effective in preventing tooth decay in high-risk adults.1,2 High-risk individuals include those with a history of multiple cavities, gum disease, or poor oral hygiene practices.

Professional Use Designation:

PREVORA has obtained MHRA approval for the treatment of caries with a professional use designation, eliminating the need for a prescription.11 This designation allows dental hygienists and dental therapists to independently administer PREVORA, enhancing its accessibility and ease of use. Dental nurses can also apply PREVORA, under the direction of a GDC registrant.

Simplicity of Administration:

PREVORA is simply painted onto the patient’s teeth. Its application requires minimal training, no special equipment, and it can be delivered without aerosols.

Potential for Periodontal Disease Management:

As well as caries prevention, PREVORA has demonstrated notable potential in managing gum disease.3-6 An ability to address both caries and gum disease simultaneously would provide significant additive clinical benefit.

For more information about PREVORA:

Please get in touch
  1. Symington, J.M., Perry, R., Kumar, A., Schiff, R. (2014) Efficacy of a 10% chlorhexidine coating to prevent caries in at-risk community-dwelling adults. Acta Odontol Scand, 72(7), 497–501.
  2. Banting, D.W., Papas, A., Clark, D.C., Proskin, H.M., Schultz, M., Perry, R. (2000) The effectiveness of 10% chlorhexidine varnish treatment on dental caries incidence in adults with dry mouth. Gerodontology, 17, 67–76.
  3. Nguyen, Q.V. (2021) Use of high-concentration chlorhexidine (PREVORA®) for reduction in ‘need for surgery’ in patients with periodontitis. Master’s thesis, University of Toronto.
  4. Sveistrup H., Pepe A., DeHaan, I., Tenenbaum H.C., Turgeon, B., Svendrovski, A. Perry, R. (2023) A time-limited randomized, controlled trial and feasibility study of delivering a preventive dental procedure to high-risk seniors in the community: the Ottawa Seniors’ Oral Health Study. [Manuscript submitted for publication].
  5. DiNardo, J. (2018) Preventing poor oral health in older patients with multiple chronic conditions. Oh Canada, Summer, 21–25.
  6. DiNardo, J. (2022) PREVORA is a successful therapy for chronic oral inflammation. [Unpublished data on file, CHX Technologies Inc].
  7. Poppolo Deus, F., Ouanounou, A. (2022) Chlorhexidine in dentistry: pharmacology, uses, and adverse effects. Int Dent J, 72(3), 269–277.
  8. Haydari, M., Bardakci, A.G., Koldsland, O.C., Aass, A.M., Sandvik, L., Preus, H.R. (2017) Comparing the effect of 0.06% -, 0.12% and 0.2% chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: a parallel group, double masked randomized clinical trial. BMC Oral Health 17(1):118.
  9. Puig Silla, M., Montiel Company, J.M., Almerich Silla, J.M. (2008) Use of chlorhexidine varnishes in preventing and treating periodontal disease. A review of the literature. Med Oral Patol Oral Cir Bucal, 13(4), E257–260.
  10. Mahendra, A., Koul, M., Upadhyay, V., Dwivedi, R. (2014) Comparative evaluation of antimicrobial substantivity of different concentrations of chlorhexidine as a root canal irrigant: An in vitro study. J Oral Biol Craniofac Res. 4(3):181–185.
  11. SUMMARY OF PRODUCT CHARACTERISTICS, 2011, ‘PREVORA 100mg/ml Dental Solution’, Medicines and Healthcare products Regulatory Agency. Available at: https://mhraproducts4853.blob.core.windows.net/docs/29aee40011bd3c3d2e1de7e8e43efbb24d94e1d6